Description

Cysteinylcobalamin CAS NO 60659-91-8 is a specialized organocobalt compound, a derivative of vitamin B12 where a cysteine residue is coordinated to the central cobalt ion. This unique structure makes it a valuable biochemical precursor and research standard for studying cobalamin metabolism and enzyme cofactors. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers involved in advanced biochemical synthesis and metabolic pathway analysis.

Application

• Biochemical Research Standard: Used as a reference compound and precursor in studies of B12-dependent enzymes, including methionine synthase and methylmalonyl-CoA mutase.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel cobalamin-based pharmaceuticals and targeted therapies.
• Nutritional Science Studies: Employed in research to investigate the absorption, transport, and cellular uptake mechanisms of different cobalamin forms.
• Enzyme Cofactor Synthesis: A critical starting material for the preparation of active enzyme cofactors and labeled cobalamin derivatives for tracer studies.
• Diagnostic Reagent Development: Used in the development and calibration of diagnostic assays for measuring vitamin B12 and related metabolites in clinical samples.

Basic Information

Product Name	Cysteinylcobalamin
CAS No.	60659-91-8
Molecular Formula	C72H106CoN18O17PS
Molecular Weight	1578.7 g/mol
Synonyms	Cysteine-Cobalamin Conjugate; Cobalamin-Cysteine Complex; Vitamin B12-Cysteine Adduct; Cys-Cbl; Cob(II)alamin-Cysteine; (Cysteinyl)cobalamin; Cysteine coordinated cobalamin; B12-Cysteine Derivative
EINECS	Contact for details

Quality Control

Our Cysteinylcobalamin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via UV-Vis and mass spectrometry, to ensure it meets the exacting standards required for research and synthesis. A detailed Certificate of Analysis (COA) documenting purity, assay, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. For long-term storage, consider keeping under an inert atmosphere to maximize stability. Keep the container sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Dark red to brown crystalline or amorphous powder
Identification (UV-Vis)	Conforms
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (Cobalamin Content)	≥ 90.0% (on dried basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.