Description

Hemoglobin A, Carbamylated is a chemically modified derivative of human hemoglobin A, where specific amino groups have been converted to carbamyl groups. This modification is critical for research into non-enzymatic protein glycation and serves as a key reference standard in clinical diagnostics. It is primarily utilized by researchers and manufacturers in the fields of biochemistry, hematology, and in-vitro diagnostics. The compound is essential for developing and calibrating assays that measure carbamylated hemoglobin, a valuable marker for assessing uremic toxicity and long-term blood glucose control.

Application

• Clinical Research & Diagnostic Development: Serves as a primary reference material for the development, validation, and calibration of clinical assays measuring carbamylated hemoglobin (CarHb) levels.
• Biomarker Studies: Used as a standard in studies investigating carbamylated proteins as biomarkers for renal failure (uremia) and metabolic disorders.
• Biochemical Research: Employed in fundamental research on non-enzymatic post-translational modifications of proteins, protein structure-function relationships, and the biochemical effects of urea and cyanate.
• Quality Control in IVD Manufacturing: Acts as a critical quality control (QC) standard for in-vitro diagnostic (IVD) kit manufacturers to ensure assay accuracy and reproducibility.
• Hematology Reference: Provides a defined modified hemoglobin standard for comparative studies against other hemoglobin variants like glycated hemoglobin (HbA1c).
• Methodology Comparison: Used as a common standard to compare the performance of different analytical techniques such as HPLC, immunoassays, and mass spectrometry.

Basic Information

Product Name	Hemoglobin A, Carbamylated
CAS No.	60616-87-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Carbamylated Hemoglobin A; Car-Hb; Carbamylated HbA; Hemoglobin A (Carbamylated); HbA, Carbamylated; CarbHb; Uremic Hemoglobin Standard; Cyanate-Modified Hemoglobin
EINECS	Contact for details

Quality Control

Our Hemoglobin A, Carbamylated is produced under strict quality management protocols. Each batch is subjected to rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identification, and other relevant parameters is provided with every shipment to guarantee traceability and support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term stability, consider storage at -20°C under desiccant.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (HPLC/UV-Vis)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Protein Content (Biuret)	≥ 90%
Carbamylation Level	Specified range per batch (COA)
Solubility	Soluble in aqueous buffers
Moisture Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.