Description

Diiodo-α-Bungarotoxin is a chemically modified, radiolabeled derivative of the potent neurotoxin α-Bungarotoxin, specifically engineered for advanced research applications. This compound is critical for high-sensitivity studies of nicotinic acetylcholine receptors (nAChRs), enabling precise localization and quantification. It is an essential tool for researchers and institutions in neuroscience, pharmacology, and toxicology who require reliable, high-specificity ligands for receptor binding assays and autoradiography.

Application

• Receptor Binding Assays: High-affinity, radiolabeled ligand for the quantitative study of nicotinic acetylcholine receptor (nAChR) density and kinetics.
• Autoradiography: Used in histological studies to map and visualize the distribution of nAChRs in tissue sections of the brain, muscle, and other organs.
• Neuroscience Research: A key tool for investigating the role of nAChRs in neurological functions, disorders, and the mechanisms of neurotoxins.
• Pharmacological Screening: Employed in drug discovery to evaluate the potency and selectivity of novel compounds targeting the nAChR.
• Toxicology Studies: Used to study the binding site and mode of action of snake venom toxins and related neuroactive agents.
• Biochemical Characterization: Essential for purifying and characterizing nAChR subtypes from various biological sources.

Basic Information

Product Name	Diiodo-α-Bungarotoxin
CAS No.	60616-86-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	α-Bungarotoxin, Iodinated; 125I-α-Bungarotoxin; Iodo-α-Bungarotoxin; Radioiodinated α-Bungarotoxin; α-BGTX; α-Bungarotoxin, diiodo-; nAChR Antagonist; Neuronal Nicotinic Receptor Blocker
EINECS	Contact for details

Quality Control

Our Diiodo-α-Bungarotoxin is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and high biological activity for research. Each lot is subjected to rigorous analytical testing, including assessment of purity and specific radioactivity. A comprehensive Certificate of Analysis (COA) detailing purity, specific activity, and analytical methods is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store frozen at -20°C or below. Due to its hygroscopic (moisture-sensitive) nature, the product should be handled in a dry environment and allowed to equilibrate to room temperature before opening to prevent condensation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Specific Activity	Contact for details
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.