Description

(E)-Ethyl 4-(4-Fluorophenyl)-4-Oxobut-2-Enoate is a high-purity fluorinated organic intermediate with significant synthetic utility. Its core value lies in its role as a versatile building block for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research chemists and process development scientists working on active pharmaceutical ingredients (APIs), advanced materials, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the fluorophenyl moiety for enhanced biological activity and stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials with tailored properties.
• Chemical Biology & Proteomics: Employed as a scaffold or labeling reagent in the design of molecular probes and enzyme inhibitors for biochemical research.
• Academic & Industrial R&D: A valuable reagent for method development and exploratory synthesis in organic chemistry laboratories worldwide.

Basic Information

Product Name	(E)-Ethyl 4-(4-Fluorophenyl)-4-Oxobut-2-Enoate
CAS No.	60611-95-2
Molecular Formula	C12H11FO3
Molecular Weight	222.21 g/mol
Synonyms	Ethyl (E)-4-(4-Fluorobenzoyl)acrylate; (E)-Ethyl 4-(4-Fluorobenzoyl)-2-butenoate; 4-(4-Fluorophenyl)-4-oxo-2-butenoic Acid Ethyl Ester; trans-Ethyl 4-(4-Fluorobenzoyl)acrylate; 2-Butenoic acid, 4-(4-fluorophenyl)-4-oxo-, ethyl ester, (E)-; Ethyl (E)-4-(4-fluorobenzoyl)but-2-enoate; 60611-95-2; Ethyl 4-(4-fluorophenyl)-4-oxobut-2-enoate
EINECS	Contact for details

Quality Control

Our (E)-Ethyl 4-(4-Fluorophenyl)-4-Oxobut-2-Enoate is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach ambient temperature before opening to minimize moisture ingress. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.