Description

Fenofibryl Glucuronide is a key metabolite of fenofibrate, a widely used pharmaceutical agent. This compound is of significant importance in pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It serves as a critical reference standard for laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors requiring high-purity materials for analytical and developmental work.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for quantitative analysis in drug metabolism and pharmacokinetic (DMPK) studies.
• Bioanalytical Method Development: Essential for developing and validating HPLC, LC-MS, and LC-MS/MS methods to quantify fenofibrate and its metabolites in biological matrices.
• Metabolite Identification & Profiling: Used in research to identify, characterize, and understand the metabolic pathways of fenofibrate in preclinical and clinical studies.
• Quality Control in Manufacturing: Acts as a system suitability standard and an impurity control standard in the quality assurance of fenofibrate active pharmaceutical ingredient (API) and finished dosage forms.
• Toxicology and Safety Assessment: Employed in studies to assess the safety profile and potential toxicity of fenofibrate metabolites.
• Academic and Institutional Research: Supports pharmacological and biochemical research in universities and government institutions focused on lipid metabolism and cardiovascular diseases.

Basic Information

Product Name	Fenofibryl Glucuronide
CAS No.	60318-63-0
Molecular Formula	C24H28O10
Molecular Weight	476.47 g/mol
Synonyms	1-{4-[(4-Chlorophenyl)carbonyl]phenoxy}-2-methylpropyl β-D-Glucopyranosiduronic Acid; Fenofibric Acid Glucuronide; Fenofibrate Glucuronide; Fenofibric Acid 1-O-β-Glucuronide; 2-{4-[(4-Chlorobenzoyl)phenoxy]}-2-methylpropanoic Acid β-D-Glucuronide; CP 68199 (Glucuronide Metabolite); Isopropyl 2-[p-(p-Chlorobenzoyl)phenoxy]-2-methylpropionate Glucuronide
EINECS	Contact for details

Quality Control

Our Fenofibryl Glucuronide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic data, ensuring the material meets the high standards required for pharmaceutical reference standards and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.