Description

Neurotoxin-1, Naja Naja Oxiana is a highly specific and potent neurotoxic polypeptide isolated from the venom of the Central Asian cobra. This compound is of significant value in biochemical and pharmacological research due to its selective antagonism of nicotinic acetylcholine receptors. It is an essential tool for researchers in neuroscience, toxicology, and drug discovery who require high-purity, biologically active toxins for receptor binding studies, mechanism of action investigations, and the development of novel therapeutics or antivenoms.

Application

• Neuroscience Research: As a selective antagonist for studying the structure and function of nicotinic acetylcholine receptors (nAChRs) in the central and peripheral nervous systems.
• Pharmacological Studies: Used in vitro and in vivo to investigate synaptic transmission, neuromuscular blockade, and the pathophysiology of neurotoxicity.
• Drug Discovery & Development: A key tool for screening and evaluating potential antidotes, antivenoms, and novel therapeutic agents targeting neurotoxic pathways.
• Toxicology & Safety Assessment: Employed as a reference standard in assays to detect and quantify cobra venom toxins or to study the efficacy of neutralizing antibodies.
• Biochemical Reagent: Used in protein interaction studies, affinity chromatography, and the purification of specific receptor subtypes.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in cell signaling, ion channel physiology, and venom biology.

Basic Information

Product Name	Neurotoxin-1, Naja Naja Oxiana
CAS No.	60318-12-9
Molecular Formula	CnHmNoOpSq (Polypeptide)
Molecular Weight	~7-8 kDa (Contact for details)
Synonyms	Naja naja oxiana Neurotoxin 1; Oxiana Neurotoxin; NT-1; Cobra Neurotoxin; Short-chain Neurotoxin; α-Neurotoxin; Postsynaptic Neurotoxin; Acetylcholine Receptor Antagonist; Venom Toxin; CAS 60318-12-9
EINECS	Contact for details

Quality Control

Our Neurotoxin-1, Naja Naja Oxiana is produced and handled under stringent conditions to ensure batch-to-batch consistency and biological activity. Each lot is subjected to a comprehensive suite of analytical tests, including purity assessment by HPLC, peptide sequencing, and functional activity assays. A Certificate of Analysis (COA) detailing purity, potency, and test results is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C or below to minimize freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under anhydrous conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Biological Activity (LD50 assay)	Contact for details
Protein Content (UV)	≥ 90%
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in water or saline

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.