Description

Cytosine β-D-Arabinoside, [Cytosine-5-3H] is a tritium-labeled derivative of the nucleoside analog cytarabine (ara-C). This radiolabeled compound is an essential tool for tracing and quantifying the metabolic pathways, cellular uptake, and pharmacokinetics of its parent drug in biological research. It is primarily used by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) engaged in oncology and antiviral drug development.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Tracing the absorption, distribution, metabolism, and excretion (ADME) of cytarabine.
• Biochemical Pathway Analysis: Investigating the mechanism of action, including incorporation into DNA and inhibition of DNA synthesis.
• Autoradiography and Imaging: Used as a tracer in tissue distribution studies for pre-clinical cancer research.
• Enzyme Assay Substrate: Serving as a labeled substrate for studies involving deoxycytidine kinase and other nucleoside-metabolizing enzymes.
• Cellular Uptake and Transport Studies: Quantifying the influx and efflux mechanisms in target cells, relevant to drug resistance research.
• Quality Control Reference Standard: Acting as an internal standard in analytical methods like LC-MS for quantification of cytarabine and its metabolites.

Basic Information

Product Name	Cytosine β-D-Arabinoside, [Cytosine-5-3H]
CAS No.	60299-13-0
Molecular Formula	C9H133HN3O5
Molecular Weight	Contact for details
Synonyms	1-β-D-Arabinofuranosyl[5-3H]cytosine; [5-3H]Cytarabine; Tritiated Cytarabine; Ara-C-[5-3H]; Cytosine Arabinoside-[5-3H]; β-D-Arabinofuranosylcytosine, [5-3H]-; 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone, [5-3H]-
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled compounds is produced and tested under stringent quality protocols. Certificates of Analysis (COA) are provided, detailing critical parameters such as radiochemical purity (by HPLC), specific activity, and chemical purity. Our quality systems ensure traceability and consistency for research integrity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at or below -20°C in the original solvent as supplied. Store in accordance with all local and national regulations for radioactive materials.

Specification

Item	Specification
Appearance	Clear solution
Identification (HPLC)	Conforms
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	Contact for details (Ci/mmol)
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol:Water (7:3) or as specified
Concentration	1 mCi/mL (or as specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.