Description

[Ala2 , Leu5 ]-Enkephalin CAS NO 60284-47-1 is a synthetic pentapeptide analog of the endogenous opioid peptide enkephalin, featuring alanine and leucine substitutions. This compound is a critical research tool for studying opioid receptor pharmacology, signal transduction, and pain modulation pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience and analgesic drug discovery.

Application

• Neuroscience Research: Used as a selective ligand in receptor binding assays and functional studies to investigate delta (δ) and mu (μ) opioid receptor subtypes.
• Pharmacological Studies: Serves as a reference standard and active agent in vitro and in vivo to study the physiological effects of enkephalin analogs on pain perception and neuroregulation.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening (HTS) assays for identifying novel opioid receptor modulators.
• Drug Discovery & Development: Acts as a key intermediate or reference compound in the design and synthesis of new peptide-based analgesic candidates with improved stability and efficacy.
• Academic & Clinical Research: Supports fundamental research into the endogenous opioid system, its role in addiction, mood disorders, and gastrointestinal motility.

Basic Information

Product Name	[Ala2 , Leu5 ]-Enkephalin
CAS No.	60284-47-1
Molecular Formula	C28H37N5O7
Molecular Weight	555.63 g/mol
Synonyms	H-Tyr-Ala-Gly-Phe-Leu-OH; (5-L-Leucine,2-L-alanine)-Enkephalin; DALE; [Ala2,Leu5]-Enkephalin; Enkephalin, [Ala(2)-Leu(5)]-; L-Leucine, L-tyrosyl-L-alanylglycyl-L-phenylalanyl-; Tyr-Ala-Gly-Phe-Leu; Alanine-leucine enkephalin
EINECS	Contact for details

Quality Control

Our [Ala2 , Leu5 ]-Enkephalin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results to ensure the material meets the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95.0%
Single Impurity (HPLC)	≤2.0%
Water Content (KF)	≤8.0%
Peptide Content (AAA)	≥80.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.