Description

(Met(O)5)-Enkephalin CAS NO 60283-51-4 is a chemically modified analog of the endogenous opioid peptide [Met5]-enkephalin, where the methionine residue is oxidized to methionine sulfoxide. This modification is of significant interest in biochemical and pharmacological research for studying peptide stability, receptor interaction, and oxidative stress pathways. It serves as a critical tool compound for neuroscientists, pharmacologists, and medicinal chemists focused on the opioid system, neurobiology, and peptide drug development.

Application

• Neuroscience Research: Used as a reference standard and probe to investigate the structure-activity relationships (SAR) of opioid peptides and their receptors.
• Pharmacological Studies: Employed in in vitro and in vivo assays to study the effects of peptide oxidation on biological activity, potency, and metabolic stability.
• Biochemical Analysis: Serves as a substrate or standard in enzymatic studies, mass spectrometry, and HPLC method development for peptide analysis.
• Medicinal Chemistry: A key intermediate or analog in the design and synthesis of novel peptide-based therapeutics targeting pain management and neurological disorders.
• Oxidative Stress Models: Utilized in research models to understand the role of methionine oxidation in protein/peptide function and disease pathology.

Basic Information

Product Name	(Met(O)5)-Enkephalin
CAS No.	60283-51-4
Molecular Formula	C27H35N5O7S
Molecular Weight	573.66 g/mol
Synonyms	[Met(O)5]-Enkephalin; Methionine Sulfoxide-Enkephalin; H-Tyr-Gly-Gly-Phe-Met(O)-OH; Oxidized [Met5]-Enkephalin; YGGFM(O); Opioid Peptide Analog; L-Tyrosylglycylglycyl-L-phenylalanyl-L-methionine (S-oxide); (5-L-Methionine S-oxide)-enkephalin
EINECS	Contact for details

Quality Control

Our (Met(O)5)-Enkephalin is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Peptide Content	≥80%
Single Impurity (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.