Description

Benzo(A)Pyrene Diolepoxide I is a critical metabolite and reference standard of the potent environmental carcinogen Benzo[a]pyrene. This compound is essential for research into the mechanisms of polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis and DNA adduct formation. It is primarily utilized by toxicology research laboratories, environmental testing facilities, and academic institutions studying metabolic activation pathways and biomarker development.

Application

• Toxicological Research Standard: Used as a definitive reference material in studies investigating the metabolic activation pathways of Benzo[a]pyrene to its ultimate carcinogenic forms.
• DNA Adduct Analysis: Serves as a critical standard for the identification and quantification of specific DNA adducts formed by PAH exposure, crucial for molecular epidemiology and biomarker studies.
• Environmental Carcinogenesis Studies: Employed in in vitro and in vivo models to elucidate the mechanisms of PAH-induced cancer and to assess genotoxic potential.
• Analytical Method Development: Used as a high-purity calibrant in the development and validation of sensitive analytical methods such as HPLC-MS/MS and GC-MS for detecting PAH metabolites.
• Biomonitoring and Exposure Assessment: Acts as a key standard in assays designed to measure human exposure to complex PAH mixtures from sources like air pollution, cigarette smoke, and charred food.
• Regulatory and Safety Testing: Supports safety assessments and regulatory compliance testing for chemicals and environmental samples requiring detailed mutagenicity and carcinogenicity profiling.

Basic Information

Product Name	Benzo(A)Pyrene Diolepoxide I
CAS No.	60268-85-1
Molecular Formula	C₂₀H₁₂O₃
Molecular Weight	300.31 g/mol
Synonyms	(±)-anti-Benzo[a]pyrene-7,8-diol-9,10-epoxide; BPDE I; anti-BPDE; 7β,8α-Dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (anti); Benzo[a]pyrene diolepoxide I; anti-Benzo[a]pyrene diolepoxide; 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti isomer)
EINECS	Contact for details

Quality Control

Our Benzo(A)Pyrene Diolepoxide I is produced and handled under strict quality-controlled conditions to ensure the highest standards of purity and stability required for sensitive research applications. Each batch is thoroughly characterized using advanced analytical techniques, including HPLC and spectroscopic methods, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to support your research integrity and data traceability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the container to reach room temperature in a desiccator before opening to prevent condensation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Solubility	Soluble in DMSO, Acetone

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.