Description

1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-Tetraacetic Acid is a high-purity, macrocyclic chelating agent and a key intermediate in the synthesis of advanced contrast agents for medical imaging. This compound matters for its exceptional ability to form stable, inert complexes with various metal ions, particularly gadolinium, which is critical for safety and efficacy in diagnostic applications. It is primarily needed by manufacturers in the pharmaceutical and biotechnology sectors for developing next-generation MRI contrast media and for research in inorganic chemistry and radiopharmaceuticals.

Application

• MRI Contrast Agent Precursor: The primary application is as a critical building block (ligand) for synthesizing gadolinium-based contrast agents (GBCAs) used in magnetic resonance imaging (MRI).
• Radiopharmaceutical Development: Serves as a bifunctional chelator for labeling antibodies, peptides, or other targeting molecules with diagnostic or therapeutic radionuclides (e.g., 64Cu, 68Ga, 177Lu).
• Research Chemical: Used in academic and industrial research to study coordination chemistry, metal ion sequestration, and the development of new metal-organic frameworks (MOFs) or catalysts.
• Analytical Reagent: Employed in analytical chemistry as a selective complexing agent for the separation, detection, or quantification of specific metal ions in complex matrices.
• Industrial Catalyst Ligand: Can be utilized to design homogeneous catalysts for various organic synthesis reactions, leveraging its multidentate coordination properties.

Basic Information

Product Name	1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-Tetraacetic Acid
CAS No.	60239-22-7
Molecular Formula	C18H32N4O8
Molecular Weight	432.47 g/mol
Synonyms	DOTA; DOTA Acid; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid (common misnomer, but widely used); Tetraxetan; Cyclen tetraacetic acid; 1,4,8,11-Tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid; H4dota; (1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (related isomer).
EINECS	Contact for details

Quality Control

Our 1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-Tetraacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets exacting standards suitable for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.