Description

1-n-Benzyl-Proline is a chiral proline derivative where the nitrogen atom is protected by a benzyl group. This structural modification makes it a valuable building block in organic synthesis, particularly for the preparation of complex molecules where stereochemical control is critical. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of drug candidates, especially those targeting proteases and other enzymes.
• Peptide Chemistry: Used as a protected amino acid derivative for the solid-phase and solution-phase synthesis of modified peptides and peptidomimetics.
• Catalyst Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands used in asymmetric catalysis, such as organocatalysts or metal complexes.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes and inhibitors to study biological pathways and protein function.
• Agrochemical Synthesis: A potential intermediate in the production of chiral, biologically active compounds for crop protection.

Basic Information

Product Name	1-n-Benzyl-Proline
CAS No.	60169-72-4
Molecular Formula	C₁₂H₁₅NO₂
Molecular Weight	205.25 g/mol
Synonyms	N-Benzylproline; 1-Benzyl-L-proline; (S)-1-Benzylpyrrolidine-2-carboxylic acid; L-Proline, 1-benzyl-; N-Benzyl-L-proline; 1-Benzyl-2-pyrrolidinecarboxylic acid; N-Bn-Proline; N-Bn-Pro-OH
EINECS	Contact for details

Quality Control

Our 1-n-Benzyl-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.