Description

5-Amino-N,N'-Bis[2-Hydroxy-1-(Hydroxymethyl) Ethyl]-2,4,6-Triiodobenzene-1,3-Dicarboxamide is a high-purity, non-ionic iodinated organic compound that serves as a critical intermediate in the synthesis of modern X-ray contrast media. Its molecular structure is engineered for high water solubility and low osmolality, which are essential properties for safe and effective diagnostic imaging agents. This compound is primarily required by pharmaceutical manufacturers and advanced research institutions developing next-generation contrast agents for computed tomography (CT) and angiography.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing non-ionic, monomeric X-ray contrast agents like Iopamidol and Ioversol.
• Contrast Media Research: Used in R&D for developing new, safer, and more efficient iodinated contrast media with improved renal tolerance.
• Diagnostic Imaging: Serves as the core triiodinated benzene structure essential for creating agents used in CT scans, urography, and vascular imaging.
• Chemical Synthesis: Intermediate for further chemical modifications to create dimeric or other specialized contrast agent structures.
• Quality Control Standards: Can be utilized as a reference standard in analytical laboratories for method development and impurity profiling.

Basic Information

Product Name	5-Amino-N,N'-Bis[2-Hydroxy-1-(Hydroxymethyl) Ethyl]-2,4,6-Triiodobenzene-1,3-Dicarboxamide
CAS No.	60166-98-5
Molecular Formula	C14H18I3N3O8
Molecular Weight	713.02 g/mol
Synonyms	5-Amino-2,4,6-triiodoisophthalamide derivative; Iopamidol Intermediate; Ioversol Intermediate; 5-Amino-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide; 5-Amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide; ATD; Triiodinated Isophthalamide Intermediate; Non-ionic Contrast Media Precursor
EINECS	262-104-6

Quality Control

Our 5-Amino-N,N'-Bis[2-Hydroxy-1-(Hydroxymethyl) Ethyl]-2,4,6-Triiodobenzene-1,3-Dicarboxamide is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and related substances, to ensure compliance with stringent internal specifications. A comprehensive Certificate of Analysis (COA) detailing identity, assay, impurity profile, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.