Description

L-Proline, Glycyl-, 1,1-Dimethylethyl Ester CAS NO 60166-68-9 is a protected dipeptide derivative, specifically a tert-butyl ester of glycyl-L-proline, serving as a crucial building block in organic synthesis. This compound is valued for its role in facilitating complex peptide coupling reactions while protecting the carboxylic acid functionality. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetic drugs.
• Biochemical Research: Used as a building block in academic and industrial research for studying peptide structure, function, and metabolism.
• Protease Inhibitor Development: Serves as a scaffold or intermediate in the design and synthesis of enzyme inhibitors targeting proteases.
• Combinatorial Chemistry: Employed in the generation of diverse chemical libraries for high-throughput screening in drug discovery programs.
• Gly-Pro Dipeptide Analog Synthesis: Fundamental for creating analogs of the endogenous glycyl-proline dipeptide, which has roles in cellular communication.
• Cosmeceutical Ingredient Synthesis: Potential intermediate in the production of peptide-based active ingredients for skincare formulations.

Basic Information

Product Name	L-Proline, Glycyl-, 1,1-Dimethylethyl Ester
CAS No.	60166-68-9
Molecular Formula	C11H20N2O3
Molecular Weight	228.29 g/mol
Synonyms	Glycyl-L-proline tert-butyl ester; H-Gly-Pro-OtBu; Boc-Gly-Pro-OH (common error, note: this is the Boc-protected variant); Gly-Pro-OtBu; tert-Butyl glycyl-L-prolinate; N-Glycyl-L-proline 1,1-dimethylethyl ester; L-Proline, N-glycyl-, 1,1-dimethylethyl ester; Glycine, N-L-prolyl-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our L-Proline, Glycyl-, 1,1-Dimethylethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.