Description

(3S,αr)-3-[[[4-[(R)-3-Amino-3-Carboxypropoxy]Phenyl][(E)-Hydroxyimino]Acetyl]Amino]-α-(4-Hydroxyphenyl)-2-Oxo-1-Azetidineacetic Acid is a complex, high-purity azetidinone derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel β-lactam antibiotics and other biologically active molecules. It is essential for research institutions and pharmaceutical manufacturers engaged in the synthesis of next-generation antimicrobial agents and targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel β-lactam antibiotics, including advanced penicillins and cephalosporins.
• Antimicrobial Agent Research: Used as a core structural component in studies aimed at overcoming bacterial resistance mechanisms.
• Bioconjugation & Prodrug Development: Utilized in creating targeted drug delivery systems due to its reactive functional groups (amino, carboxyl).
• Enzyme Inhibitor Synthesis: Serves as a precursor for designing inhibitors of bacterial cell wall synthesis enzymes.
• Chemical Biology & Proteomics: Employed as a tool compound for studying enzyme-substrate interactions and mechanism-based inhibition.
• Process Chemistry & Scale-Up: Supplied for process optimization and pilot-scale synthesis of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(3S,αr)-3-[[[4-[(R)-3-Amino-3-Carboxypropoxy]Phenyl][(E)-Hydroxyimino]Acetyl]Amino]-α-(4-Hydroxyphenyl)-2-Oxo-1-Azetidineacetic Acid
CAS No.	60134-71-6
Molecular Formula	C23H24N4O9
Molecular Weight	500.46 g/mol
Synonyms	3-[[[4-[(R)-3-Amino-3-carboxypropoxy]phenyl][(E)-hydroxyimino]acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid; (3S,αR)-3-[[[4-[(R)-3-Amino-3-carboxypropoxy]phenyl][(E)-hydroxyimino]acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid; Azetidineacetic acid derivative; β-lactam intermediate; CAS 60134-71-6
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical R&D and pre-clinical applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to confirm identity, chiral purity, and chemical integrity. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic data and impurity profiles. Quality systems are designed to support work under cGMP guidelines for investigational materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0% de
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.