Description

β-Tbu-Dl-Alanine is a non-natural, sterically hindered amino acid derivative featuring a tert-butyl group on the β-carbon. This unique structure makes it a valuable chiral building block and intermediate in advanced organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies for the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs). The compound's properties are critical for modulating the conformation, stability, and bioavailability of target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex peptide-based drugs and protease inhibitors.
• Peptidomimetic Research: Used to introduce steric bulk and conformational constraints in the design of peptide mimics with enhanced metabolic stability.
• Chiral Auxiliary/Synthon: Serves as a precursor for chiral ligands, catalysts, and resolving agents in asymmetric synthesis.
• Biochemical Research: Employed in studies of enzyme-substrate interactions and protein folding due to its structure-disrupting properties.
• Material Science: Potential monomer for creating specialized polymers with unique thermal and mechanical characteristics.
• Agrochemical Development: Intermediate in the synthesis of novel, biologically active compounds for crop protection.

Basic Information

Product Name	β-Tbu-Dl-Alanine
CAS No.	60122-72-7
Molecular Formula	C7H15NO2
Molecular Weight	145.20 g/mol
Synonyms	3-Amino-4,4-dimethylpentanoic acid; DL-3-Amino-4,4-dimethylpentanoic acid; (±)-3-Amino-4,4-dimethylpentanoic acid; β-(tert-Butyl)-DL-alanine; 3-(tert-Butylamino)propanoic acid (related); BOC-DL-β-tert-butyl-Ala-OH (protected derivative); Tbu-Ala
EINECS	Contact for details

Quality Control

Our β-Tbu-Dl-Alanine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support compliance with REACH and other relevant global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (DL Ratio)	~50:50 (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.