Description

Valproic Acid B-D-Glucuronide is a major, pharmacologically relevant metabolite of the anticonvulsant drug valproic acid. This compound is critical for research and development in pharmacokinetics, toxicology, and therapeutic drug monitoring. It serves as a vital reference standard and analytical tool for scientists and quality control professionals in the pharmaceutical, clinical diagnostics, and contract research organization (CRO) sectors.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantitative analysis of valproic acid and its metabolites in biological matrices.
• Metabolite Research: Essential for in vitro and in vivo studies investigating the metabolism, pharmacokinetics, and pharmacodynamics of valproic acid.
• Bioanalytical Method Development: Used to develop and validate sensitive LC-MS/MS, HPLC, and GC-MS methods for therapeutic drug monitoring (TDM).
• Clinical Toxicology: Acts as a calibrator or control in assays designed to measure valproic acid metabolite levels for overdose cases or compliance testing.
• Drug Impurity Profiling: Employed in the identification and quantification of glucuronidated impurities or related substances in valproic acid drug substance and product.
• Enzymatic Activity Studies: Useful as a substrate for studying the activity of UDP-glucuronosyltransferase (UGT) enzymes.

Basic Information

Product Name	Valproic Acid B-D-Glucuronide
CAS No.	60113-83-9
Molecular Formula	C16H26O9
Molecular Weight	362.37 g/mol
Synonyms	2-Propylpentanoic acid 1-β-D-glucopyranuronoside; Valproic Acid 1-O-β-D-Glucuronide; Valproic Acid β-D-Glucuronide; VPA-G; Valproate Glucuronide; 1-O-(2-Propylpentanoyl)-β-D-glucopyranuronic acid; β-D-Glucopyranosiduronic acid, 2-propylpentanoate
EINECS	Contact for details

Quality Control

Our Valproic Acid B-D-Glucuronide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for research and analytical applications. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.