Description

1-(Difluoromethoxy)-1,2,2-Trifluoroethane is a specialized fluorinated organic compound with the CAS number 60113-74-8. This chemical is valued for its unique combination of volatility and fluorine content, making it a versatile intermediate and solvent in advanced manufacturing. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical sectors for applications requiring precise fluorination or inert, high-performance media.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the introduction of fluorine or difluoromethoxy groups to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a key building block in the production of advanced herbicides, fungicides, and insecticides where fluorinated compounds improve efficacy and environmental profile.
• Specialty Solvent: Acts as a high-performance solvent for sensitive reactions and purification processes in fine chemical synthesis, leveraging its volatility and chemical inertness.
• Refrigerant & Propellant Research: Investigated as a potential component in next-generation, low-global-warming-potential (GWP) refrigerant blends and aerosol propellants due to its fluorinated structure.
• Electronic Chemicals: Employed in the cleaning and etching stages for precision electronics manufacturing, where high purity and controlled volatility are critical.
• Polymer Modification: Used as a monomer or modifier in the synthesis of specialty fluoropolymers to impart specific surface properties and chemical resistance.

Basic Information

Item	Details
Product Name	1-(Difluoromethoxy)-1,2,2-Trifluoroethane
CAS No.	60113-74-8
Molecular Formula	C3H3F5O
Molecular Weight	150.04 g/mol
Synonyms	1,2,2-Trifluoro-1-(difluoromethoxy)ethane; HFE-356mmz; 2,2,2-Trifluoroethyl difluoromethyl ether; Difluoromethyl 2,2,2-trifluoroethyl ether; 1-(Difluoromethoxy)-1,1,2,2,2-pentafluoroethane (common misnomer); F3C-CH2-O-CHF2; R-356mmz
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethoxy)-1,2,2-Trifluoroethane is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency suitable for demanding industrial and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept upright and sealed when not in use. Recommended storage temperature is 2-8°C to minimize vapor pressure and maintain stability for long-term storage.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (20°C)	~1.45 g/mL
Boiling Point	~40-45°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.