Description

Sulindac Sulfone Acyl-β-D-Glucuronide is a key metabolite and reference standard of the non-steroidal anti-inflammatory drug (NSAID) Sulindac. This compound is critical for pharmaceutical research and development, particularly in studies of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in drug discovery and regulatory compliance activities.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the identification and quantification of Sulindac metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance mechanisms, and bioavailability of Sulindac.
• Bioanalytical Method Development: Used to calibrate and validate analytical methods such as HPLC, LC-MS, and LC-MS/MS for accurate metabolite profiling.
• Toxicology and Safety Assessment: Employed in studies to understand the safety profile and potential toxicological effects of Sulindac and its metabolites.
• Impurity Profiling: Acts as a marker for impurity identification and control during the manufacturing and quality control of Sulindac-based pharmaceuticals.
• Clinical Research: Supports clinical studies monitoring patient drug metabolism and ensuring therapeutic efficacy and safety.

Basic Information

Product Name	Sulindac Sulfone Acyl-β-D-Glucuronide
CAS No.	60018-37-3
Molecular Formula	C₂₀H₂₄O₁₀S
Molecular Weight	456.47 g/mol
Synonyms	(Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid β-D-glucopyranosiduronic acid; Sulindac Sulfone Glucuronide; Sulindac Sulfone Acyl Glucuronide; Acyl-β-D-Glucuronide of Sulindac Sulfone; Sulindac Sulfone Acylglucuronide
EINECS	Contact for details

Quality Control

Our Sulindac Sulfone Acyl-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical reference materials. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for identity, purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	≤ 2.0% total
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.