Description

n-(2-Hydroxyethyl)-2,2,2-trifluoroacetamide is a versatile trifluoroacetamide derivative, recognized for its unique combination of a polar hydroxyethyl group and a stable trifluoroacetyl moiety. This compound is valued as a key synthetic intermediate and building block in advanced organic synthesis, particularly for introducing fluorine-containing functional groups. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel active ingredients and materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of fluorinated drug candidates, including protease inhibitors and other bioactive molecules.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Peptide Modification: Acts as a reagent for the selective modification of peptides and proteins, leveraging the reactivity of the acetamide group.
• Ligand and Catalyst Preparation: Employed in the preparation of specialized ligands and organocatalysts for asymmetric synthesis and metal complexation.
• Material Science Research: Functions as a monomer or precursor for synthesizing fluorinated polymers and advanced materials with specific surface properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	n-(2-Hydroxyethyl)-2,2,2-trifluoroacetamide
CAS No.	6974-29-4
Molecular Formula	C4H6F3NO2
Molecular Weight	157.09 g/mol
Synonyms	2,2,2-Trifluoro-N-(2-hydroxyethyl)acetamide; N-(2-Hydroxyethyl)trifluoroacetamide; 2-Hydroxyethyltrifluoroacetamide; 2,2,2-Trifluoroacetamide, N-(2-hydroxyethyl)-; Ethanol, 2-[(trifluoroacetyl)amino]-; Trifluoroacetic acid 2-hydroxyethylamide; TFAEA; HETA
EINECS	230-200-3

Quality Control

Our n-(2-Hydroxyethyl)-2,2,2-trifluoroacetamide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect product quality and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.