Description

Tris[2-(Methoxymethyl)Phenyl]Phosphane is a specialized organophosphorus ligand with a unique steric and electronic profile, making it highly valuable in advanced catalytic transformations. Its primary commercial significance lies in its role as a key ligand for transition metal catalysts, particularly in cross-coupling reactions essential for pharmaceutical and fine chemical synthesis. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for developing efficient and selective synthetic routes.

Application

• As a ligand in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Buchwald-Hartwig amination, and Negishi couplings.
• For the development of homogeneous catalysts used in the synthesis of complex organic molecules and active pharmaceutical ingredients (APIs).
• In academic and industrial research for exploring new catalytic methodologies and reaction mechanisms.
• As a key intermediate or additive in the preparation of specialized materials, including OLED precursors and liquid crystals.
• For process optimization in fine chemical manufacturing, where high selectivity and yield are paramount.

Basic Information

Product Name	Tris[2-(Methoxymethyl)Phenyl]Phosphane
CAS No.	6962-89-6
Molecular Formula	C27H33O3P
Molecular Weight	436.52 g/mol
Synonyms	Tris(2-(Methoxymethyl)phenyl)phosphine; Tris(o-(Methoxymethyl)phenyl)phosphine; 2-(Methoxymethyl)phenylphosphine, tris-; Tris(2-methoxymethylphenyl)phosphane; Phosphine, tris[2-(methoxymethyl)phenyl]-; Ligand SPhos (Note: SPhos is a closely related, widely known ligand; this compound is a specific variant/analog); Tris(2-methoxymethylphenyl)phosphine; (2-Methoxymethylphenyl)phosphine, tris-
EINECS	Contact for details

Quality Control

Our Tris[2-(Methoxymethyl)Phenyl]Phosphane is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity, which is critical for catalytic performance. All products undergo rigorous analytical testing, including NMR and HPLC, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
31P NMR	Conforms
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.