Description

3-Oxo-16β-Acetoxy-14,15β-Epoxy-5β-Bufa-20,22-Dienolide is a high-purity, complex steroidal lactone derivative, specifically a bufadienolide, valued for its role as a critical advanced intermediate in pharmaceutical research and development. Its intricate molecular architecture makes it a key building block for synthesizing novel bioactive compounds and for studying structure-activity relationships. This product is primarily targeted at research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the development of new therapeutic agents, particularly in the fields of cardiology and oncology.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel cardiac glycosides and other steroidal drugs.
• Biochemical Research: Used as a reference standard or probe in pharmacological studies to investigate ion channel (Na+/K+-ATPase) modulation and cellular signaling pathways.
• Medicinal Chemistry: Serves as a core scaffold for the design and synthesis of new chemical entities with potential anti-cancer or cardiotonic activity.
• Academic Research: Employed in university and institutional labs for studying the chemistry and biology of bufadienolides and cardenolides.
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis to create more complex, functionalized steroid derivatives.

Basic Information

Item	Details
Product Name	3-Oxo-16β-Acetoxy-14,15β-Epoxy-5β-Bufa-20,22-Dienolide
CAS No.	6869-66-5
Molecular Formula	C₂₆H₃₄O₆
Molecular Weight	442.55 g/mol
Synonyms	16β-Acetoxy-14β,15β-epoxy-3-oxo-5β-bufa-20,22-dienolide; 14β,15β-Epoxy-3-oxo-16β-acetoxy-5β-bufa-20,22-dienolide; Bufadienolide derivative; 3-Oxo-16β-acetoxy-14β,15β-epoxy-5β-bufa-20,22-dienolide; 5β-Bufa-20,22-dienolide, 16β-(acetyloxy)-14β,15β-epoxy-3-oxo-
EINECS	Contact for details

Quality Control

Our 3-Oxo-16β-Acetoxy-14,15β-Epoxy-5β-Bufa-20,22-Dienolide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, IR, MS) for structural confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its light-sensitive nature, the container should be kept in secondary packaging or amber glass to prevent degradation from light exposure. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.