Description

Imipramine n-Oxide is a key pharmaceutical intermediate and metabolite of the tricyclic antidepressant imipramine. This compound is of significant importance in research and development for studying drug metabolism, pharmacokinetics, and for the synthesis of related active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in neuropharmacology and analytical chemistry.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and development of tricyclic antidepressant drugs and related analogs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical methods (e.g., HPLC, LC-MS) for quantifying imipramine and its metabolites in biological matrices during pharmacokinetic studies.
• Biochemical Research: Employed in neuroscience and pharmacology research to investigate the metabolic pathways, efficacy, and side-effect profiles of imipramine.
• Quality Control & Method Development: Serves as a certified reference material (CRM) in pharmaceutical quality control laboratories for assay validation and impurity profiling.
• Academic Research: Used in university and institutional labs for studies on cytochrome P450 metabolism and drug-drug interactions.

Basic Information

Product Name	Imipramine n-Oxide
CAS No.	6829-98-7
Molecular Formula	C19H24N2O
Molecular Weight	296.41 g/mol
Synonyms	Imipramine N-Oxide; Imipramine Oxide; 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine N-Oxide; Desipramine N-Oxide Precursor; Imipramine Metabolite; 10,11-Dihydro-5-(3-(dimethylamino)propyl)-5H-dibenz[b,f]azepine 5-Oxide; N-Desmethylimipramine N-Oxide Intermediate
EINECS	Contact for details

Quality Control

Our Imipramine n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed chromatograms and spectral data to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.