Description

Benzyl (2,2,2-Trifluoro-1-Hydroxyethyl)Carbamate is a specialized fluorinated carbamate derivative, serving as a crucial chiral building block and protective group intermediate in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoromethyl and carbamate functionalities, enabling precise molecular construction. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active ingredients and complex molecules requiring high stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially those incorporating fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental profile.
• Peptide Chemistry: Functions as a protective group for amines during solid-phase and solution-phase peptide synthesis, offering orthogonal deprotection strategies.
• Asymmetric Synthesis: Employed in catalytic asymmetric reactions to construct stereogenic centers, valuable for creating enantiomerically pure compounds.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced materials with specific surface properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	Benzyl (2,2,2-Trifluoro-1-Hydroxyethyl)Carbamate
CAS No.	6798-33-0
Molecular Formula	C10H10F3NO3
Molecular Weight	249.19 g/mol
Synonyms	Carbamic acid, N-[(1S)-2,2,2-trifluoro-1-hydroxyethyl]-, phenylmethyl ester; (S)-Benzyl (2,2,2-trifluoro-1-hydroxyethyl)carbamate; Benzyl N-[(1S)-2,2,2-trifluoro-1-hydroxyethyl]carbamate; (S)-Benzyloxycarbonylamino(trifluoromethyl)methanol; N-Cbz-2,2,2-trifluoroethanolamine; N-[(1S)-2,2,2-Trifluoro-1-hydroxyethyl]carbamic Acid Benzyl Ester; (S)-1-Benzyloxycarbonylamino-2,2,2-trifluoroethanol
EINECS	Contact for details

Quality Control

Our Benzyl (2,2,2-Trifluoro-1-Hydroxyethyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.