Description

N1'-Carboxybiotin is a key biotin derivative and a crucial intermediate in the synthesis of biotinylated compounds. This compound matters for its role in the development of high-affinity biochemical probes, diagnostic reagents, and pharmaceutical research. It is primarily needed by manufacturers and R&D teams in the pharmaceutical, biotechnology, and life sciences sectors for applications in affinity chromatography, enzyme assays, and targeted drug delivery systems.

Application

• Bioconjugation and Labeling: A vital intermediate for synthesizing biotinylated antibodies, proteins, and nucleic acids for use in immunoassays (ELISA, Western Blot) and diagnostic kits.
• Affinity Chromatography: Used to functionalize resins and surfaces for the purification of streptavidin/avidin-tagged biomolecules.
• Pharmaceutical Research: Serves as a building block in the development of novel drug candidates and targeted therapeutics that utilize the biotin-streptavidin interaction.
• Enzyme Inhibition Studies: Employed in biochemical research to study biotin-dependent enzymes, such as carboxylases, due to its structural similarity to biotin.
• Diagnostic Reagent Manufacturing: A critical raw material in producing high-sensitivity detection reagents for clinical and research diagnostics.
• Chemical Synthesis: An advanced intermediate for the custom synthesis of more complex biotin analogs and molecular probes.

Basic Information

Product Name	N1'-Carboxybiotin
CAS No.	6706-15-6
Molecular Formula	C11H18N2O4S
Molecular Weight	274.34 g/mol
Synonyms	1'-N-Carboxybiotin; Biotin N-Carboxylic Acid; (+)-Biotin N-Carboxylic Acid; D-Biotin N-Carboxylic Acid; Biotin-1'-carboxylic acid; 5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid; Vitamin H N-carboxylic acid
EINECS	Contact for details

Quality Control

Our N1'-Carboxybiotin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.