Description

[4-(2,5-Dioxopyrrol-1-Yl)Phenyl] Acetate is a specialized chemical intermediate featuring a reactive maleimide group linked to a phenyl acetate moiety. This compound matters for its dual functionality, enabling conjugation with thiols via Michael addition while the acetate group offers a site for further chemical modification or cleavage. It is primarily needed by researchers and manufacturers in the pharmaceutical and bioconjugation sectors for developing antibody-drug conjugates (ADCs), peptide labeling, and advanced polymer synthesis.

Application

• Bioconjugation Reagent: Key intermediate for the synthesis of antibody-drug conjugates (ADCs) and protein labeling via thiol-maleimide chemistry.
• Pharmaceutical Intermediate: Used in the research and development of targeted therapeutics and prodrugs.
• Polymer Chemistry: Serves as a functional monomer or crosslinker for creating smart polymers and hydrogels with responsive properties.
• Peptide Modification: Enables site-specific modification of cysteine-containing peptides for diagnostic and therapeutic applications.
• Material Science: Employed in surface functionalization and the creation of advanced functional materials.
• Research & Development: A valuable tool compound in chemical biology and medicinal chemistry for exploring new bioconjugation strategies.

Basic Information

Product Name	[4-(2,5-Dioxopyrrol-1-Yl)Phenyl] Acetate
CAS No.	6637-46-3
Molecular Formula	C12H9NO4
Molecular Weight	231.20 g/mol
Synonyms	1-[4-(Acetyloxy)phenyl]-1H-pyrrole-2,5-dione; 4-Maleimidophenyl acetate; N-(4-Acetoxyphenyl)maleimide; p-Acetoxyphenylmaleimide; 4-(Maleimidophenyl) acetate; Acetic acid 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenyl ester; 1-(4-Acetoxyphenyl)-1H-pyrrole-2,5-dione
EINECS	Contact for details

Quality Control

Our [4-(2,5-Dioxopyrrol-1-Yl)Phenyl] Acetate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.