Description

Ac-Mac (Masked Acyl Cyanide) is a versatile and highly reactive chemical building block used in advanced organic synthesis. Its unique masked functionality allows for controlled reactivity, making it a valuable reagent for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking efficient pathways for introducing acyl cyanide equivalents.

Application

• Pharmaceutical Intermediates: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for heterocyclic compounds and complex amines.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides requiring specific cyanide or nitrile functionalities.
• Peptide Chemistry: Acts as a coupling agent or protecting group strategy in the synthesis of peptides and peptide mimetics.
• Material Science: Building block for polymers and advanced materials where controlled cyanide incorporation is needed.
• Organic Synthesis: Acyl anion equivalent for nucleophilic acylation reactions and the preparation of α-ketonitriles.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.

Basic Information

Product Name	Ac-Mac (Masked Acyl Cyanide)
CAS No.	6625-70-3
Molecular Formula	C4H5NO2
Molecular Weight	99.09 g/mol
Synonyms	1-Cyanoethyl Acetate; Acetoxyacetonitrile; 2-Acetoxyacetonitrile; Acetyl Cyanide, Methyl Ester; Cyanomethyl Acetate; Acetoxymethyl Cyanide; 2-Acetoxyethanenitrile; (Acetoxymethyl)cyanide
EINECS	229-580-6

Quality Control

Our Ac-Mac (Masked Acyl Cyanide) is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including assay by GC or HPLC, identity confirmation (IR, NMR), and impurity profiling to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.