Description

L-Phenylalanine, L-Leucyl-, Methyl Ester, Monohydrochloride is a protected dipeptide derivative, specifically the methyl ester hydrochloride salt of the L-Phenylalanyl-L-Leucine dipeptide. This compound is a crucial building block (synthon) in advanced organic synthesis, particularly for the production of complex peptides and peptidomimetics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in drug discovery and development processes.

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase and solution-phase synthesis of novel therapeutic peptides and peptide-based drug candidates.
• Biochemical Research: Used as a substrate or standard in enzymatic studies, proteomics research, and metabolic pathway investigations.
• Peptidomimetic Development: Serves as a core structural unit for designing and synthesizing peptidomimetics, which mimic the function of natural peptides but with enhanced stability and bioavailability.
• Custom Peptide Synthesis: An essential starting material for contract research organizations (CROs) and CDMOs producing custom peptides for clients in academia and industry.
• Protecting Group Strategy: The methyl ester and hydrochloride salt functionalities offer specific protection and solubility properties useful in multi-step synthetic routes.

Basic Information

Product Name	L-Phenylalanine, L-Leucyl-, Methyl Ester, Monohydrochloride
CAS No.	6461-07-0
Molecular Formula	C17H25N2O3 • HCl
Molecular Weight	332.85 g/mol
Synonyms	L-Phenylalanyl-L-leucine methyl ester hydrochloride; H-Phe-Leu-OMe • HCl; Methyl L-phenylalanyl-L-leucinate hydrochloride; (S)-Methyl 2-((S)-2-amino-3-phenylpropanamido)-4-methylpentanoate hydrochloride; L-Leucine, L-phenylalanyl-, methyl ester, hydrochloride; Phe-Leu-OMe • HCl; N-(L-Phenylalanyl)-L-leucine methyl ester hydrochloride; F-L-OMe • HCl
EINECS	Contact for details

Quality Control

Our L-Phenylalanine, L-Leucyl-, Methyl Ester, Monohydrochloride is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation (IR, NMR). A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.