Description

n-Benzyloxycarbonyl-D-Proline is a protected derivative of the non-proteinogenic amino acid D-proline, widely used as a key chiral building block in organic synthesis. This compound is essential for the controlled synthesis of peptides and peptidomimetics, where it provides stereochemical integrity and prevents racemization. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Peptide Synthesis: A fundamental chiral intermediate for the solid-phase and solution-phase synthesis of complex peptides containing D-proline residues.
• Pharmaceutical Intermediates: Serves as a critical precursor in the production of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Protease Inhibitor Development: Used in the research and manufacturing of inhibitors targeting specific proteases, which are relevant in virology and oncology.
• Bioconjugation & Labeling: Employed in the preparation of labeled peptides for diagnostic and research applications.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in asymmetric catalytic reactions to construct complex molecular architectures.
• Academic & Industrial R&D: A standard reagent in chemical research for exploring new synthetic methodologies and bioactive compound libraries.

Basic Information

Product Name	n-Benzyloxycarbonyl-D-Proline
CAS No.	6404-31-5
Molecular Formula	C13H15NO4
Molecular Weight	249.26 g/mol
Synonyms	Z-D-Proline; (R)-1-((Benzyloxy)carbonyl)pyrrolidine-2-carboxylic acid; D-Proline, N-[(phenylmethoxy)carbonyl]-; Cbz-D-Proline; N-Carbobenzoxy-D-proline; N-Benzyloxycarbonyl-D-proline; (R)-2-(((Benzyloxy)carbonyl)amino)pentanedioic acid 5-ethyl ester (related); NSC 3349
EINECS	Contact for details

Quality Control

Our n-Benzyloxycarbonyl-D-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.