Description

Z-Leu-Phe-OH is a protected dipeptide derivative, widely utilized as a crucial building block in peptide synthesis. Its primary value lies in providing a controlled and efficient method for constructing longer, more complex peptide chains, particularly in solid-phase peptide synthesis (SPPS). This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing novel therapeutic peptides and biochemical tools.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex therapeutic peptides and peptidomimetics.
• Solid-Phase Peptide Synthesis (SPPS): Used extensively in Fmoc/t-Bu and Boc/Bzl strategies for the controlled elongation of peptide sequences.
• Biochemical Research: Employed in the study of enzyme-substrate interactions, protease specificity, and peptide hormone analogs.
• Combinatorial Chemistry: Serves as a versatile scaffold for generating diverse peptide libraries for drug discovery and screening.
• Custom Peptide Production: A fundamental component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptides.
• Protease Inhibitor Development: Acts as a substrate or inhibitor analog in the design of compounds targeting specific proteolytic enzymes.

Basic Information

Product Name	Z-Leu-Phe-OH
CAS No.	6401-63-4
Molecular Formula	C23H28N2O5
Molecular Weight	412.48 g/mol
Synonyms	N-Carbobenzoxy-L-leucyl-L-phenylalanine; Z-L-Leu-L-Phe-OH; CBZ-Leu-Phe; Nα-Cbz-L-leucyl-L-phenylalanine; Benzyloxycarbonyl-L-leucyl-L-phenylalanine; (2S)-2-[[(2S)-4-Methyl-1-oxo-1-[[(phenylmethoxy)carbonyl]amino]pentan-2-yl]amino]-3-phenylpropanoic acid; N-Benzyloxycarbonylleucylphenylalanine; Z-Leu-Phe
EINECS	Contact for details

Quality Control

Our Z-Leu-Phe-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.