Description

Ac-Trp-NHMe is a protected tryptophan derivative, specifically an N-acetyl tryptophan methylamide. This compound is a crucial building block in peptide synthesis and medicinal chemistry research, offering a protected indole side chain that is essential for constructing complex bioactive peptides. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in the development of peptide-based therapeutics, enzyme inhibitors, and biochemical probes.

Application

• Peptide Synthesis Intermediate: A key protected amino acid derivative for solid-phase and solution-phase peptide synthesis (SPPS).
• Medicinal Chemistry Research: Serves as a building block for developing novel peptide drugs, enzyme inhibitors, and receptor ligands.
• Biochemical Tool Development: Used in the synthesis of fluorescent probes, affinity tags, and other research reagents that incorporate a tryptophan moiety.
• Structure-Activity Relationship (SAR) Studies: Enables the study of peptide conformation and bioactivity by providing a modified tryptophan residue.
• Reference Standard: Acts as a chromatographic or spectroscopic standard in analytical method development for peptide APIs and impurities.

Basic Information

Product Name	Ac-Trp-NHMe
CAS No.	6367-17-5
Molecular Formula	C₁₅H₁₉N₃O₂
Molecular Weight	273.33 g/mol
Synonyms	N-Acetyl-L-tryptophan N'-methylamide; Ac-L-Trp-NHMe; Nα-Acetyl-L-tryptophan methylamide; (S)-2-Acetamido-3-(1H-indol-3-yl)-N-methylpropanamide; Acetyl-L-tryptophan methylamide; L-Tryptophan, N-acetyl-, methylamide; N-Acetyltryptophan methylamide
EINECS	Contact for details

Quality Control

Our Ac-Trp-NHMe is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.