Description

1-Cyclohexyl-2,2,2-trifluoro-ethanone is a specialized fluorinated ketone building block of significant interest in advanced organic synthesis. Its unique structure, featuring a cyclohexyl group and a trifluoroacetyl moiety, makes it a valuable precursor for introducing lipophilic and electron-withdrawing properties into target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of complex molecules, particularly for introducing the trifluoroacetyl group which can enhance metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the fluorinated ketone structure contributes to biological activity.
• Ligand and Catalyst Preparation: Acts as a precursor for chiral ligands or metal-organic frameworks (MOFs) used in asymmetric catalysis.
• Material Science: Employed in the synthesis of fluorinated polymers or liquid crystals with specific thermal and optical properties.
• Organic Synthesis Building Block: Utilized in various reactions, including nucleophilic additions, reductions to chiral alcohols, and as a component in multi-step synthetic routes.

Basic Information

Product Name	1-Cyclohexyl-2,2,2-trifluoro-ethanone
CAS No.	6302-04-1
Molecular Formula	C8H11F3O
Molecular Weight	180.17 g/mol
Synonyms	Cyclohexyl Trifluoroacetate; 2,2,2-Trifluoro-1-cyclohexylethanone; Trifluoroacetylcyclohexane; Cyclohexyl Trifluoromethyl Ketone; α,α,α-Trifluoroacetophenone, Cyclohexyl-; 1-Cyclohexyl-2,2,2-trifluoroethan-1-one; Cyclohexyl trifluoroacetyl ketone
EINECS	228-577-7

Quality Control

Our 1-Cyclohexyl-2,2,2-trifluoro-ethanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.