Description

Phenylthioacetylene is a specialized organosulfur building block featuring a terminal alkyne group bonded to a phenylthio moiety. This unique structure makes it a valuable reagent in advanced organic synthesis, particularly for constructing complex sulfur-containing molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as click chemistry and heterocycle synthesis.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially those containing thioether or acetylene functional groups.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides where the phenylthioacetylene unit can impart specific biological activity.
• Material Science Research: Serves as a monomer or precursor in the development of advanced polymers and organic electronic materials.
• Click Chemistry Reagent: Its terminal alkyne group participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and polymer functionalization.
• Ligand Synthesis: Employed in the preparation of specialized sulfur-containing ligands for catalysis and coordination chemistry.
• Heterocyclic Compound Construction: A versatile precursor for the synthesis of various sulfur and nitrogen-containing heterocycles, which are common scaffolds in medicinal chemistry.

Basic Information

Product Name	Phenylthioacetylene
CAS No.	6228-98-4
Molecular Formula	C8H6S
Molecular Weight	134.20 g/mol
Synonyms	Ethyne, (phenylthio)-; (Phenylthio)acetylene; Phenyl thioacetylene; Benzenethiol, S-ethynyl-; S-Ethynylbenzenethiol; Phenyl acetylene sulfide; Thiophenol acetylene; Phenylsulfanylacetylene
EINECS	228-324-5

Quality Control

Our Phenylthioacetylene is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and structural confirmation, to ensure it meets the high standards required for research and process chemistry. A Certificate of Analysis (COA) detailing specific results for purity, identity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.