Description

Quinidine Hydrochloride is a high-purity pharmaceutical salt of the classic antiarrhythmic alkaloid, quinidine. It serves as a critical active pharmaceutical ingredient (API) and a vital reference standard in cardiovascular research and drug development. This compound is essential for manufacturers and research institutions in the pharmaceutical, biotechnology, and analytical chemistry sectors requiring a reliable source of this key therapeutic agent.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the hydrochloride salt in the formulation of antiarrhythmic medications for treating atrial fibrillation and other cardiac conditions.
• Pharmacological Research: A fundamental tool for studying cardiac ion channels (particularly sodium and potassium channels), mechanisms of arrhythmia, and drug interactions.
• Analytical Reference Standard: Used in quality control laboratories for HPLC, UV, and titration methods to assay drug products and raw materials.
• Biochemical Studies: Employed in in vitro and ex vivo experiments to investigate its effects on muscle contraction and electrophysiology.
• Chemical Synthesis Intermediate: Serves as a starting material or precursor for the synthesis of more complex quinidine-derived compounds or for salt metathesis reactions.

Basic Information

Product Name	Quinidine Hydrochloride
CAS No.	6151-40-2
Molecular Formula	C20H24N2O2·HCl
Molecular Weight	360.88 g/mol
Synonyms	Quinidine HCl; (8S,9R)-6'-Methoxycinchonan-9-ol hydrochloride; Cinchonan-9-ol, 6'-methoxy-, (8α,9R)-, hydrochloride; Quinidine monohydrochloride; Quinidine chloride; Conchinine hydrochloride; Pitayine hydrochloride; β-Quinidine hydrochloride
EINECS	228-164-5

Quality Control

Our Quinidine Hydrochloride is manufactured under strict quality management systems. It undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical use. A Certificate of Analysis (COA) detailing all test results is provided with each batch to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed after opening to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Specific Rotation	+223° to +229° (c=2 in 0.1M HCl)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.