Description

o-(4-Hydroxy-3-Iodophenyl)-3,5-Diiodo-L-Tyrosine Hydrochloride is a high-purity iodinated aromatic amino acid derivative, primarily utilized as a critical intermediate in advanced pharmaceutical synthesis. Its value lies in providing a structurally complex, halogenated scaffold essential for developing novel therapeutic agents and diagnostic compounds. This product is specifically needed by research institutions and pharmaceutical manufacturers focused on endocrinology, radiopharmaceuticals, and the development of thyroid hormone analogs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel thyroid hormone receptor agonists and antagonists.
• Radiopharmaceutical Precursor: Serves as a precursor for iodine-123 or iodine-131 labeled compounds used in diagnostic imaging and therapy.
• Biochemical Research: Used in studies investigating thyroid hormone metabolism, deiodinase enzyme activity, and cellular signaling pathways.
• Reference Standard: Employed as an analytical standard in HPLC and LC-MS methods for quality control and metabolic studies.
• Organic Synthesis: Valuable intermediate for constructing complex, polyhalogenated organic molecules with potential biological activity.

Basic Information

Product Name	o-(4-Hydroxy-3-Iodophenyl)-3,5-Diiodo-L-Tyrosine Hydrochloride
CAS No.	6138-47-2
Molecular Formula	C15H11I3NO4 • HCl
Molecular Weight	739.87 g/mol
Synonyms	3,5-Diiodo-o-(4-hydroxy-3-iodophenyl)tyrosine hydrochloride; 3,5-Diiodothyronine Hydrochloride; 3,5-T2 Hydrochloride; 3,3',5-Triiodothyronine impurity; L-3,5-Diiodothyronine HCl; o-(4-Hydroxy-3-iodophenyl)-3,5-diiodotyrosine hydrochloride; T2 Hydrochloride
EINECS	Contact for details

Quality Control

Our o-(4-Hydroxy-3-Iodophenyl)-3,5-Diiodo-L-Tyrosine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets stringent specifications for research and pharmaceutical use. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.