Description

n-Tosyllysine Methyl Ester is a protected amino acid derivative primarily used as a key synthetic intermediate in organic and peptide chemistry. Its value lies in providing a versatile building block for the controlled synthesis of complex molecules, particularly in pharmaceutical research and development. This compound is essential for scientists and manufacturers in the life sciences sector who require high-purity intermediates for producing peptides, enzyme inhibitors, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in proteomics and enzymology studies, particularly as a substrate or inhibitor for enzymes like trypsin and other serine proteases.
• Peptide Synthesis: Serves as a protected lysine derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Chemical Biology Probes: Employed in the development of activity-based probes (ABPs) to study enzyme function and mechanism.
• Organic Synthesis: Acts as a chiral synthon for the preparation of more complex, non-peptide organic molecules.

Basic Information

Product Name	n-Tosyllysine Methyl Ester
CAS No.	6072-04-4
Molecular Formula	C15H24N2O4S
Molecular Weight	328.43 g/mol
Synonyms	N(6)-Tosyl-L-lysine Methyl Ester; L-Lysine, N6-[(4-methylphenyl)sulfonyl]-, methyl ester; Methyl N(6)-tosyl-L-lysinate; TLCK; Tosyl-L-lysine chloromethyl ketone precursor; N-α-Tosyl-L-lysine methyl ester; TLME; N(epsilon)-Tosyl-L-lysine methyl ester
EINECS	Contact for details

Quality Control

Our n-Tosyllysine Methyl Ester is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be kept under an inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Contact for details
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.