Description

Difluoromethylidenecyclohexane is a specialized fluorinated organic building block of significant interest in advanced chemical synthesis. Its unique structure, featuring a gem-difluoroalkene moiety integrated into a cyclohexyl ring, makes it a valuable precursor for introducing fluorinated segments into target molecules, which can dramatically alter their physical, chemical, and biological properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries to create novel compounds with enhanced metabolic stability, bioavailability, or lipophilicity.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for introducing fluorinated motifs to improve drug-like properties.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and pesticides where fluorine incorporation can increase efficacy and environmental persistence.
• Material Science Research: Acts as a monomer or modifier in the development of specialty polymers and coatings with unique surface characteristics or stability.
• Liquid Crystal & Electronic Chemicals: Employed in the synthesis of fluorinated components for liquid crystal displays (LCDs) and other electronic materials.
• Organic Synthesis Building Block: Provides a versatile handle for cycloaddition reactions, cross-coupling, and other transformations in complex molecule construction.
• Catalysis & Ligand Development: Investigated for use in developing novel fluorinated ligands for transition metal catalysis.

Basic Information

Product Name	Difluoromethylidenecyclohexane
CAS No.	696-32-2
Molecular Formula	C7H10F2
Molecular Weight	132.15 g/mol
Synonyms	1,1-Difluoro-1-cyclohexene; Cyclohexylidenedifluoromethane; 1-Cyclohexene, 1,1-difluoro-; 1,1-Difluorocyclohexene; Difluoromethylenecyclohexane; (Difluoromethylene)cyclohexane; NSC 5186
EINECS	211-798-6

Quality Control

Our Difluoromethylidenecyclohexane is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. For customers with specific regulatory needs, we can support documentation for GMP or ISO-guided applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture ingress and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.05 g/cm³
Boiling Point	~125-130°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.