Description

4,4,4-Trifluorobut-2-En-1-Ol is a versatile fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoromethyl group and the terminal alcohol functionality, enabling the construction of complex molecules with tailored properties. This compound is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the trifluoromethyl group into drug candidates, potentially enhancing metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to incorporate fluorine into polymer backbones or side chains, altering surface properties, chemical resistance, and thermal stability.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Heck, Suzuki) for creating complex fluorinated aromatic and heteroaromatic systems.
• Asymmetric Synthesis: The prochiral alkene and alcohol groups make it a valuable starting material for chiral catalyst development and enantioselective synthesis.

Basic Information

Item	Details
Product Name	4,4,4-Trifluorobut-2-En-1-Ol
CAS No.	674-53-3
Molecular Formula	C4H5F3O
Molecular Weight	126.08 g/mol
Synonyms	4,4,4-Trifluorobut-2-en-1-ol; 4,4,4-Trifluoro-2-buten-1-ol; 3-(Trifluoromethyl)allyl alcohol; 4,4,4-Trifluorobut-2-enol; 2-Buten-1-ol, 4,4,4-trifluoro-; (E/Z)-4,4,4-Trifluorobut-2-en-1-ol; Trifluoromethyl allyl alcohol
EINECS	211-618-5

Quality Control

Our 4,4,4-Trifluorobut-2-En-1-Ol is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. This material is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0% (Area %)
Isomeric Ratio (E/Z)	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.