Description

Acetic Acid, Difluoro(Trifluoromethoxy)- CAS NO 674-13-5 is a specialized fluorinated acetic acid derivative, characterized by its unique difluoro and trifluoromethoxy substituents. This compound is a high-value intermediate prized for its ability to introduce fluorine-containing motifs, which are critical for modifying the physical, chemical, and biological properties of target molecules. It is essential for R&D and production teams in the pharmaceutical and agrochemical sectors, where it is used to develop novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atoms improve weatherfastness and biological activity.
• Advanced Material Precursor: Serves as a monomer or modifier in the production of specialty polymers and coatings with enhanced chemical resistance and surface properties.
• Liquid Crystal & Electronic Chemicals: Employed in the synthesis of fluorinated components for liquid crystal displays (LCDs) and dielectric fluids.
• Organic Synthesis Reagent: A versatile reagent in academic and industrial laboratories for introducing the -CF2CO2H moiety into complex organic frameworks.

Basic Information

Product Name	Acetic Acid, Difluoro(Trifluoromethoxy)-
CAS No.	674-13-5
Molecular Formula	C3HF5O3
Molecular Weight	180.03 g/mol
Synonyms	2,2-Difluoro-2-(trifluoromethoxy)acetic Acid; (Trifluoromethoxy)difluoroacetic Acid; Difluoro(trifluoromethoxy)acetic Acid; α,α-Difluoro-α-(trifluoromethoxy)acetic Acid; TFMO-Difluoroacetic Acid; Perfluoromethoxyacetic Acid (historical); Acetic acid, 2,2-difluoro-2-(trifluoromethoxy)-; EINECS 211-618-1
EINECS	211-618-1

Quality Control

Every batch of Acetic Acid, Difluoro(Trifluoromethoxy)- is manufactured and tested under a strict quality management system. We provide comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles, ensuring traceability and consistency for your critical synthesis workflows. Our quality commitment supports compliance with ISO standards and relevant REACH regulations for the global market.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its nature as a fluoride/strong alkali reactive and highly volatile compound, keep away from heat, sparks, and incompatible materials. Ensure containers are kept upright and securely sealed to prevent moisture ingress and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.55 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.