Description

4-Chloro-3-Iodobenzotrifluoride is a high-value halogenated aromatic building block, distinguished by its unique combination of chlorine, iodine, and trifluoromethyl substituents. This trifunctional intermediate is critical for introducing specific steric and electronic properties into advanced molecular architectures. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical sectors for constructing complex active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The iodine and chlorine atoms provide orthogonal reactivity for sequential Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions.
• Material Science Research: Employed in the creation of novel polymers and ligands with tailored properties for catalysis and sensing applications.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in chemical manufacturing.

Basic Information

Item	Detail
Product Name	4-Chloro-3-Iodobenzotrifluoride
CAS No.	672-57-1
Molecular Formula	C7H3ClF3I
Molecular Weight	305.45 g/mol
Synonyms	1-Chloro-4-(trifluoromethyl)-2-iodobenzene; 2-Iodo-4-chlorobenzotrifluoride; 4-Chloro-α,α,α-trifluoro-3-iodotoluene; 3-Iodo-4-chlorobenzotrifluoride; 4-Chloro-3-iodo-α,α,α-trifluorotoluene; 4-Chloro-3-iodo-(trifluoromethyl)benzene; 2-Iodo-4-chloro-α,α,α-trifluorotoluene; Benzene, 1-chloro-4-(trifluoromethyl)-2-iodo-
EINECS	211-593-7

Quality Control

Our 4-Chloro-3-Iodobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.