Description

1-Bromo-3-(Pentafluorosulfanyl)Benzene is a high-value, multi-functional aromatic building block distinguished by its unique combination of bromine and pentafluorosulfanyl (SF5) functional groups. This compound matters for its exceptional role as a key intermediate in advanced organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and specialty materials where the introduction of the highly electronegative and lipophilic SF5 group is desired. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate novel fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates incorporating the pentafluorosulfanyl group to modulate bioavailability, metabolic stability, and lipophilicity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the SF5 moiety can enhance biological activity and environmental persistence profiles.
• Liquid Crystal & OLED Material Precursor: Acts as a building block for advanced electronic materials, including liquid crystals and organic light-emitting diodes (OLEDs), due to the influence of the SF5 group on molecular polarity and packing.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl and conjugated systems.
• Fluorinated Polymer Research: Employed in the research and development of specialty polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Ligand & Catalyst Development: Utilized for synthesizing novel fluorinated ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Bromo-3-(Pentafluorosulfanyl)Benzene
CAS No.	672-30-0
Molecular Formula	C6H4BrF5S
Molecular Weight	283.06 g/mol
Synonyms	3-Bromo-1-(Pentafluorosulfanyl)benzene; m-Bromo(pentafluorosulfanyl)benzene; 3-Bromophenylsulfur pentafluoride; 1-Bromo-3-(SF5)benzene; Benzene, 1-bromo-3-(pentafluorosulfanyl)-; 3-Bromo-alpha,alpha,alpha,alpha',alpha',alpha'-hexafluorothioanisole; (3-Bromophenyl)sulfur pentafluoride
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(Pentafluorosulfanyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber-colored or stored in opaque secondary packaging.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.