Description

2-Fluorofumarate (CAS NO 672-18-4) is a high-value fluorinated derivative of fumaric acid, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a fluorine atom on an unsaturated dicarboxylate, enables precise modulation of electronic and steric properties in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, including protease inhibitors and kinase modulators.
• Agrochemical Research: Used in the synthesis of novel herbicides and pesticides, where the fluorine atom can improve lipophilicity and target binding.
• Material Science: Acts as a monomer or cross-linking agent for creating specialty polymers with tailored properties.
• Biochemical Probe Development: Utilized in medicinal chemistry to study enzyme mechanisms and receptor interactions via fluorine NMR (19F NMR).
• Peptide Mimetics: Incorporated into peptide backbones to enhance stability against enzymatic degradation.
• Fluorine Chemistry Library Synthesis: A valuable scaffold for generating diverse compound libraries in high-throughput screening for drug discovery.

Basic Information

Product Name	2-Fluorofumarate
CAS No.	672-18-4
Molecular Formula	C4H3FO4
Molecular Weight	134.06 g/mol
Synonyms	2-Fluorobut-2-enedioate; (E)-2-Fluorobut-2-enedioic Acid; trans-2-Fluorofumaric Acid; Fluorofumaric Acid; (E)-2-Fluorofumaric Acid; 2-Fluorofumaric Acid; (2E)-2-Fluorobut-2-enedioic Acid
EINECS	211-593-6

Quality Control

Every batch of 2-Fluorofumarate is manufactured under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant techniques is supplied with each shipment. Our quality protocols are designed to support applications in cGMP and ISO-compliant environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light to maintain stability and purity. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.