Description

n-Ethyl-2,2-difluoroacetamide is a specialized fluorinated acetamide derivative, serving as a versatile building block in advanced organic synthesis. Its core value lies in the introduction of the difluoroacetamide moiety, a key functional group for modulating the physicochemical and biological properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors who require high-purity intermediates for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting protease inhibitors and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can enhance metabolic stability and bioavailability.
• Organic Synthesis Building Block: Employed in nucleophilic substitution and condensation reactions to introduce the difluoroacetamide group into complex molecular architectures.
• Materials Science Research: Investigated as a monomer or modifier in the development of specialty polymers with unique surface properties or stability.
• Chemical Biology Probes: Serves as a precursor for labeling reagents or activity-based probes used in proteomics and enzyme studies.

Basic Information

Product Name	n-Ethyl-2,2-difluoroacetamide
CAS No.	672-16-2
Molecular Formula	C4H7F2NO
Molecular Weight	123.10 g/mol
Synonyms	2,2-Difluoro-N-ethylacetamide; N-Ethyl-2,2-difluoroacetamide; 2,2-Difluoroacetamide, N-ethyl-; Acetamide, 2,2-difluoro-N-ethyl-; Ethyl-2,2-difluoroacetamide; N-Ethyl-α,α-difluoroacetamide; DFEA
EINECS	Contact for details

Quality Control

Our n-Ethyl-2,2-difluoroacetamide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay, impurity profile, and physical characteristics. Our quality commitment supports applications requiring high standards, including GMP-compliant pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.