Description

Ethyl 4,4-Difluoropentanoate is a high-purity fluorinated ester building block of significant importance in advanced organic synthesis. Its value lies in its role as a versatile intermediate for introducing the difluoromethylene group, a key motif in medicinal chemistry and agrochemical development. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where fluorine substitution improves efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or modifier in the development of specialty polymers with unique surface properties and chemical resistance.
• Liquid Crystal & Display Chemicals: Employed in the synthesis of fluorinated components for liquid crystal mixtures.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, esterifications, and nucleophilic substitutions to construct complex fluorinated molecules.
• Fluorine-19 NMR Spectroscopy: Can be used as a reference standard or a synthetic precursor for compounds used in biochemical labeling and imaging studies.

Basic Information

Product Name	Ethyl 4,4-Difluoropentanoate
CAS No.	659-72-3
Molecular Formula	C7H12F2O2
Molecular Weight	166.17 g/mol
Synonyms	4,4-Difluoropentanoic Acid Ethyl Ester; Ethyl 4,4-Difluorovalerate; Pentanoic acid, 4,4-difluoro-, ethyl ester; Ethyl 4,4-Difluoropentanoate; 659-72-3; Ethyl γ,γ-Difluorovalerate; NSC 406908; Valeric acid, 4,4-difluoro-, ethyl ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl 4,4-Difluoropentanoate is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure product integrity and traceability for your regulatory filings. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.395 - 1.405
Density (20°C)	1.10 - 1.20 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.