Description

3,4-Difluorophenylacetic Acid is a versatile fluorinated aromatic building block essential for advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the phenyl ring, which can dramatically influence the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Development: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluorophenyl moiety enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its ability to modify electronic properties.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid group allows for coupling reactions to create peptide analogs or for attaching fluorinated tags to biomolecules in medicinal chemistry.
• Material Science Research: Employed in the development of novel polymers and advanced materials with specific thermal and chemical resistance properties.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Suzuki-Miyaura or Heck couplings to construct complex, fluorinated biaryl structures.

Basic Information

Product Name	3,4-Difluorophenylacetic Acid
CAS No.	658-93-5
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	(3,4-Difluorophenyl)acetic Acid; 2-(3,4-Difluorophenyl)acetic Acid; 3,4-DFPA; NSC 403714; α-(3,4-Difluorophenyl)acetic Acid; Benzenacetic acid, 3,4-difluoro-; 3,4-Difluorobenzeneacetic Acid
EINECS	Contact for details

Quality Control

Our 3,4-Difluorophenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.