Description

2,3,4,5,6-Pentafluorophenylacetic Acid is a high-value fluorinated aromatic building block essential for advanced chemical synthesis. Its unique perfluorinated phenyl group makes it a critical precursor for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and sophisticated intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drugs where it enhances bioavailability and metabolic resistance.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atoms to improve product efficacy and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved performance and durability.
• Peptide Modification & Labeling: Employed to introduce fluorinated tags or labels into peptides and proteins for biochemical research and diagnostic applications.
• Material Science Research: Acts as a monomer or modifier in the development of specialty polymers and coatings with unique surface properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl structures for various applications.

Basic Information

Product Name	2,3,4,5,6-Pentafluorophenylacetic Acid
CAS No.	653-21-4
Molecular Formula	C8H3F5O2
Molecular Weight	226.10 g/mol
Synonyms	Pentafluorophenylacetic Acid; (Pentafluorophenyl)acetic Acid; 2,3,4,5,6-Pentafluorobenzeneacetic Acid; α-(Pentafluorophenyl)acetic Acid; Perfluorophenylacetic Acid; PFPA; PFPAA; NSC 163063
EINECS	211-476-5

Quality Control

We maintain stringent quality control protocols for all our fluorinated intermediates. Each batch of 2,3,4,5,6-Pentafluorophenylacetic Acid is analyzed using advanced techniques including HPLC, NMR, and GC-MS to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its acidic nature, ensure containers are made of compatible materials and are properly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	108 - 112 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.