Description

Benzeneacetic Acid, α,α-Difluoro-3-Nitro- is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a difluoromethylenated phenylacetic acid core with a strategically placed nitro group, enabling precise modifications in target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting enzyme inhibition where the difluoro and nitro substituents modulate bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides, where its fluorinated structure can enhance lipophilicity and environmental persistence.
• Advanced Material Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals with tailored electronic or optical properties.
• Fluorine Chemistry Building Block: Essential for introducing the difluoromethylene (CF2) moiety into complex organic molecules, a valuable transformation in medicinal and materials chemistry.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	Benzeneacetic Acid, α,α-Difluoro-3-Nitro-
CAS No.	650-93-1
Molecular Formula	C8H5F2NO4
Molecular Weight	217.13 g/mol
Synonyms	2,2-Difluoro-2-(3-nitrophenyl)acetic Acid; 3-Nitro-α,α-difluorophenylacetic Acid; (3-Nitrophenyl)difluoroacetic Acid; α,α-Difluoro-3-nitrobenzeneacetic Acid; Difluoro(3-nitrophenyl)acetic Acid; NSC 406106; 650-93-1
EINECS	Contact for details

Quality Control

Our Benzeneacetic Acid, α,α-Difluoro-3-Nitro- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing batch-specific results. Our quality system supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its nature as a strong acid/organic solvent, store separately from bases, oxidizing agents, and reactive metals.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.