Description

6-Hydroxydopamine Hydrobromide is a specialized neurotoxic research chemical used to selectively destroy catecholaminergic neurons. This compound matters as a critical tool for modeling Parkinson's disease and studying neurodegenerative mechanisms in preclinical research. It is primarily needed by pharmaceutical R&D departments, academic neuroscience laboratories, and contract research organizations (CROs) focused on neurological disorders.

Application

• Preclinical Neurodegenerative Disease Modeling: Used to induce selective lesions of dopaminergic and noradrenergic neurons to create animal models for Parkinson's disease research.
• Neuropharmacology Studies: Employed to investigate the mechanisms of neuronal death, oxidative stress, and the neuroprotective effects of potential drug candidates.
• Neurotoxicity Screening: Serves as a positive control or challenge agent in assays designed to evaluate the neurotoxic or neuroprotective profiles of new chemical entities.
• Sympathetic Nervous System Research: Applied in studies targeting the peripheral sympathetic nervous system due to its selective uptake by catecholamine transporters.
• Cell Culture Studies: Utilized in in vitro experiments to induce oxidative stress and apoptosis in neuronal cell lines, such as PC12 or SH-SY5Y cells.
• Mechanistic Biochemistry: A tool for studying the role of reactive oxygen species (ROS), mitochondrial dysfunction, and autophagy in neuronal cell death pathways.

Basic Information

Product Name	6-Hydroxydopamine Hydrobromide
CAS No.	636-00-0
Molecular Formula	C8H12BrNO3
Molecular Weight	250.09 g/mol
Synonyms	6-OHDA HBr; 2,4,5-Trihydroxyphenethylamine Hydrobromide; 6-Hydroxy dopamine HBr; Oxidopamine Hydrobromide; 6-Hydroxydopamine HBr; 6-Hydroxy-1,2-benzenediol, 4-(2-aminoethyl)-, hydrobromide; 5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide
EINECS	211-263-6

Quality Control

Our 6-Hydroxydopamine Hydrobromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive biomedical research. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee reproducible and reliable research outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. The product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures will lead to decomposition. Keep the container sealed and desiccated in a freezer for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.