Description

4-Bromobenzonitrile is a versatile halogenated aromatic nitrile building block essential for advanced organic synthesis. Its molecular structure, featuring both a bromine substituent and a cyano group, makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This high-purity compound is primarily utilized by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and material science industries to introduce functionalized aromatic rings into target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing substituted benzonitrile or biphenyl motifs.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides where the bromobenzonitrile scaffold provides specific biological activity.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the creation of organic electronic materials, liquid crystals, and polymers requiring bromo- and cyano-functionalized aromatic units.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Substitution: The bromine atom is readily displaced in reactions with various nucleophiles, enabling diverse functional group transformations.

Basic Information

Product Name	4-Bromobenzonitrile
CAS No.	623-00-7
Molecular Formula	C7H4BrN
Molecular Weight	182.02 g/mol
Synonyms	p-Bromobenzonitrile; 4-Bromobenzene carbonitrile; 1-Bromo-4-cyanobenzene; 4-Cyanobromobenzene; p-Cyanobromobenzene; Benzonitrile, 4-bromo-; NSC 6695; BRB
EINECS	210-767-8

Quality Control

Our 4-Bromobenzonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all relevant specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliable consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	110 - 113 °C
Loss on Drying	≤0.5%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.