Description

n-Acetyl-L-Proline is a chemically modified derivative of the amino acid L-proline, featuring an acetyl group attached to the nitrogen atom. This modification enhances its stability and alters its physicochemical properties, making it a valuable chiral building block and intermediate in sophisticated organic synthesis. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications ranging from peptide synthesis to the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected proline derivative in solid-phase and solution-phase peptide synthesis to construct complex peptide structures.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development for amino acid analysis.
• Fine Chemical Synthesis: An important intermediate for synthesizing specialty chemicals, including flavors, fragrances, and advanced materials.
• Cosmetic Ingredient: Potential use in the formulation of advanced skincare products due to its derivative nature from a collagen-building amino acid.

Basic Information

Product Name	n-Acetyl-L-Proline
CAS No.	68-95-1
Molecular Formula	C7H11NO3
Molecular Weight	157.17 g/mol
Synonyms	N-Acetyl-L-proline; L-Proline, N-acetyl-; Acetylproline; (S)-1-Acetylpyrrolidine-2-carboxylic acid; 2-Acetamidotetrahydro-2-furancarboxylic acid; NSC 33436; Ac-L-Pro-OH
EINECS	200-702-8

Quality Control

Our n-Acetyl-L-Proline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for research and industrial applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and absence of critical impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-70° to -80° (c=1 in H2O)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.